Rift Valley Fever

Priority List of Adverse events of special interest for

Rift Valley Fever

AESI: Hemorrhagic disease
Specific to Rift Valley Fever disease:
Brighton Case Definition: End of 2023
Brighton CD Companion Guide: End of 2023

AESI: Thrombocytopenic Thrombosis Syndrome
Specific to Rift Valley Fever disease:
Specific to vaccine: Adeno vectors
Brighton Case Definition: End of 2023
Brighton CD Companion Guide: End of 2023

Body System: Immunologic

AESI: Anaphylaxis
Specific to vaccine: All
vaccines
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access

AESI: Thrombocytopenia
Specific to vaccine: All
vaccines
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access

Body System: Musculoskeletal

AESI: Acute aseptic arthritis
Specific to vaccine: VSV vector
Brighton Case Definition: Click to access
Brighton CD Companion Guide: End of 2023

Body System: Neurologic

AESI: Generalized convulsion
Specific to Rift Valley Fever disease:
Specific to vaccine: All
vaccines
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access

AESI: Aseptic meningitis
Specific to vaccine: Live attenuated viral vaccine
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access

AESI: Loss of Vision (incl uveitis, retinitis, optic neuritis)
Specific to Rift Valley Fever disease:
Brighton Case Definition: Prioritized, date TBD
Brighton CD Companion Guide: Prioritized, date TBD

AESI: Encephalitis
Specific to Rift Valley Fever disease:
Specific to vaccine: Live attenuated viral vaccine
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access

AESI: Myelitis
Specific to Rift Valley Fever disease:
Specific to vaccine: Live attenuated viral vaccine
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access

AESI: Guillain Barré Syndrome
Specific to Rift Valley Fever disease:
Specific to vaccine: Some vaccines¹
Brighton CD Companion Guide: TBD

Body System: Respiratory

AESI: Acute Respiratory Distress Syndrome
Specific to Rift Valley Fever disease:
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access

Body System: Pregnancy / Perinatal Outcomes

AESI: Spontaneous abortion
Specific to Rift Valley Fever disease:
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Mid 2023

AESI: Stillbirth
Specific to Rift Valley Fever disease:
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Mid 2023

¹Some seasonal influenza vaccines; monovalent H1N1 pandemic vaccine; COVID-19 ChAdOx-1 S vaccine.

Learn more about methods and results of the creation of the Priority List of potential Adverse events of special interest relevant to Rift Valley Fever vaccine trials HERE.