Educational Resources
Educational resources from the SPEAC project for investigators, regulators, and public health professionals working in vaccine safety, including explainer videos, webinars, and training materials on AESIs, Brighton case definitions, and safety monitoring.
Featured Resource · New Overview Video
Understanding Thrombosis with Thrombocytopenia Syndrome (TTS) and Vaccine-Induced Immune Thrombocytopenia and Thrombosis (VITT)
Thrombosis with Thrombocytopenia Syndrome (TTS) is a rare but serious condition characterized by abnormal blood clotting together with a reduced platelet count. This video provides an overview of TTS and Vaccine-Induced Immune Thrombocytopenia and Thrombosis (VITT), a rare immune-mediated form of TTS identified following some adenovirus-vectored COVID-19 vaccines, and explains how standardized case definitions support consistent identification, classification, and reporting.
Topics covered
- Key characteristics of TTS and VITT
- Clinical signs and symptoms
- Diagnostic evaluation and laboratory findings
- Brighton Collaboration case definitions
- Levels of diagnostic certainty
- Standardized identification, classification, and reporting
Core Learning Library
Short-form resources designed to support consistent understanding and application of key concepts, tools, and methods in vaccine safety.
Understanding Preterm Birth as an Adverse Event of Special Interest (AESI)
Introduces preterm birth as an outcome monitored in maternal immunization studies and explains how the Brighton Collaboration’s GAIA case definition supports standardized identification, classification, and reporting.
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Understanding Guillain-Barré Syndrome (GBS) and the Brighton Case Definition
Introduces Guillain-Barré syndrome, including its clinical presentation, and explains how the Brighton case definition supports consistent case classification and vaccine safety monitoring.
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What Is a Brighton Case Definition?
Explains how Brighton case definitions are structured and used to classify adverse events consistently across studies, settings, and vaccine safety surveillance systems.
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Case Definition Companion Guides
Provides an overview of how SPEAC Companion Guides support the consistent interpretation and application of Brighton case definitions in vaccine safety research.
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Automated Brighton Classification Tool Demonstration
Demonstrates how the Automated Brighton Classification Tool supports more efficient and standardized classification of adverse events using Brighton case definitions.
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What Is a Living Systematic Review?
Explains how living systematic reviews provide continually updated evidence to support vaccine safety monitoring, research, and decision-making.
Watch video →Webinar Recordings
Longer-form sessions and expert discussions exploring vaccine safety topics, methodologies, and practical applications in greater depth.
Sensorineural Hearing Loss, Lassa Fever, and Vaccines
Examines sensorineural hearing loss in the context of Lassa fever and vaccine development, including relevant clinical and vaccine safety considerations.
Watch recording →Background Rates for Observed–Expected Analysis
Explores how background rates are selected and applied in observed–expected analyses to support vaccine safety signal assessment and interpretation.
Watch recording →Evidence at Your Fingertips: Living Systematic Reviews
Provides a detailed look at how living systematic reviews support continuous evidence monitoring, synthesis, and decision-making in vaccine safety.
Watch recording →Automated Brighton Classification (ABC) Tool
Introduces the Automated Brighton Classification Tool and demonstrates how it supports standardized assessment and classification of adverse events following immunization using Brighton Collaboration case definitions.
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