Chikungunya

Priority List of Adverse events of special interest for

C
h
i
k
u
n
g
u
n
y
a

AESI: Myocarditis / Pericarditis
Specific to Chikungunya disease:
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access

Body System: Hematologic

AESI: Thrombosis / Thromboembolism
Specific to Chikungunya disease:
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access

AESI: Hemorrhagic disease
Specific to Chikungunya disease:
Brighton Case Definition: End of 2023
Brighton CD Companion Guide: End of 2023

AESI: Thrombocytopenic Thrombosis Syndrome ²
Specific to vaccine: Adeno vectors
Brighton Case Definition: End of 2023
Brighton CD Companion Guide: End of 2023

Body System: Immunologic

AESI: Anaphylaxis
Specific to vaccine: All
vaccines
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access

AESI: Thrombocytopenia
Specific to Chikungunya disease:
Specific to vaccine: All
vaccines
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access

Body System: Musculoskeletal

AESI: Acute aseptic arthritis
Specific to vaccine: VSV vector
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Dec 2023

AESI: Acute/chronic Inflammatory Rheumatism
Specific to Chikungunya disease:
Brighton Case Definition:Prioritized, date TBD
Brighton CD Companion Guide:Prioritized, date TBD

Body System: Neurologic

AESI: Generalized convulsion
Specific to Chikungunya disease:
Specific to vaccine: All
vaccines
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access

AESI: Aseptic meningitis
Specific to Chikungunya disease:
Specific to vaccine: Live attenuated viral vaccine
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access

AESI: Acute Disseminated Encephalomyelitis
Specific to Chikungunya disease:
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access

AESI: Encephalitis
Specific to Chikungunya disease:
Specific to vaccine: Live attenuated viral vaccine
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access

AESI: Myelitis
Specific to Chikungunya disease:
Specific to vaccine: Live attenuated viral vaccine
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access

AESI: Guillain Barré Syndrome
Specific to Chikungunya disease:
Specific to vaccine: Some vaccines¹
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access

AESI: Bell’s Palsy
Specific to Chikungunya disease:
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access

AESI: Uveitis/Retinitis/Optic neuritis
Specific to Chikungunya disease:
Brighton Case Definition:Prioritized, date TBD
Brighton CD Companion Guide:Prioritized, date TBD

Body System: Skin

AESI: Alopecia
Specific to Chikungunya disease:
Brighton Case Definition: TBD
Brighton CD Companion Guide: TBD

Body System: Pregnancy / Perinatal Outcomes

AESI: Spontaneous abortion
Specific to Chikungunya disease:
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Mid 2023

AESI: Stillbirth
Specific to Chikungunya disease:
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Aug 2023

AESI: Maternal death
Specific to Chikungunya disease:
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Aug 2023

AESI: Neonatal sepsis
Specific to Chikungunya disease:
Brighton Case Definition: Click to access
Brighton CD Companion Guide: TBD

AESI: Neonatal encephalopathy
Specific to Chikungunya disease:
Brighton Case Definition: Click to access
Brighton CD Companion Guide: TBD

AESI: Neurodevelopmental delay
Specific to Chikungunya disease:
Brighton Case Definition: Click to access
Brighton CD Companion Guide: TBD

¹Some seasonal influenza vaccines; monovalent H1N1 pandemic vaccine; COVID-19 ChAdOx-1 S vaccine.

Learn more about methods and results of the creation of the Priority List of potential Adverse events of special interest relevant to Chikungunya vaccine trials HERE.

Priority List of Adverse events of special interest for

C
h
i
k
u
n
g
u
n
y
a

S
E
E

A
L
L

T
H
E

L
I
S
T
S

O
F

A
E
S
I
s

F
O
R

T
H
E

C
E
P
I

P
R
I
O
R
I
T
I
Z
E
D

P
A
T
H
O
G
E
N
S
:

S
E
E

A
L
L

T
H
E

L
I
S
T
S

O
F

A
E
S
I
s

F
O
R

T
H
E

C
E
P
I

P
R
I
O
R
I
T
I
Z
E
D

P
A
T
H
O
G
E
N
S
:

Priority List of Adverse events of special interest for

Chikungunya

SEE ALL THE LISTS OF AESIs FOR THE CEPI PRIORITIZED PATHOGENS:

SEE ALL THE LISTS OF AESIs FOR THE CEPI PRIORITIZED PATHOGENS:

C
h
i
k
u
n
g
u
n
y
a

S
E
E

A
L
L

T
H
E

L
I
S
T
S

O
F

A
E
S
I
s

F
O
R

T
H
E

C
E
P
I

P
R
I
O
R
I
T
I
Z
E
D

P
A
T
H
O
G
E
N
S
:

S
E
E

A
L
L

T
H
E

L
I
S
T
S

O
F

A
E
S
I
s

F
O
R

T
H
E

C
E
P
I

P
R
I
O
R
I
T
I
Z
E
D

P
A
T
H
O
G
E
N
S
: