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Brighton Collaboration Case Definitions

Brighton Collaboration Case Definitions

Brighton Collaboration Case Definitions are intended to:

  1. Harmonize collection and analysis of vaccine safety data throughout the vaccine life cycle and across diverse resource settings.

  2. Enable classifying cases across a range of diagnostic certainty from definite (level 1) to probable (level 2) to possible cases (level 3).

  3. Provide a definition that can be applied equally to immunized and non-immunized individuals and thus are suited for use in:

    • Determining background incidence of events of interest
    • Causality hypothesis testing studies

Brighton Collaboration Case Definitions are not intended to guide clinical case management.

Learn more about the history Brighton Collaboration

Case definitions developed by SPEAC:

See the case definitions for the adverse events of special interest developed by the CEPI-funded SPEAC project below:
Only show AESIs relevant to these pathogens:
Only show AESIs relevant to these vaccine platforms:
No more cases to show

The list above is limited and only showing the CDs developed by the CEPI-funded SPEAC project. For those who want to have a ready link to all available CDs by pathogen or platform, they can access them via the AESI list section or see all the existing CDs using the button below.

See all the published Brighton Case Definitions
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The Safety Platform for Emergency vACcines (SPEAC) is a project funded by the Coalition for Epidemic Preparedness Innovations (CEPI). SPEAC is located at Brighton Collaboration, a program of the Task Force for Global Health.

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