When it comes to vaccine safety, precision matters. That’s why the Brighton Collaboration and SPEAC have created Case Definition Companion Guides—practical tools designed to ensure case definitions are applied consistently across studies, settings, and the vaccine lifecycle.
But what exactly is a Companion Guide, and how does it work alongside a Brighton Collaboration case definition?
We recently released an explainer video that walks through the answers.
Why Companion Guides Matter
Companion Guides are step-by-step resources that:
Support consistent application of case definitions in diverse contexts
Help identify and monitor specific adverse events of special interest (AESI)
Provide tools for structured data collection and assessment of diagnostic certainty
Bridge research and practice—from clinical trials through post-marketing pharmacovigilance
By offering practical examples, checklists, and tools, these guides make it easier for researchers, regulators, and pharmacovigilance professionals to align on standards.
Who Should Watch
Whether you’re working in vaccine R&D, safety surveillance, or regulatory review, this short video offers a clear overview of how Companion Guides strengthen the Brighton Collaboration framework—and why they’re a valuable addition to your toolkit.
Learn more about Companion Guides HERE
