Living Systematic Reviews (LSRs) are comprehensive literature reviews that are continually updated, incorporating relevant new evidence as it becomes available when published in databases and clinical trial registries, which is used to conduct meta-analyses for various safety, immunogenicity and efficacy endpoints.  

A robust methodological framework, including PRISMA guidelines for reporting, ensures high-quality evidence synthesis. Including a diverse range of populations, such as children, pregnant persons, and adults, allows for a comprehensive evaluation of vaccine safety and efficacy among key at-risk groups.