In collaboration with Instituto de Efectividad Clínica y Sanitaria (IECS) and Tulane University, SPEAC’s Special Populations team has launched a Living Systematic Review focused on the safety, effectiveness, and immunogenicity of Chikungunya (CHKV) vaccines.
Access the Chikungunya Living Systematic Review here.
🔍 What is a Living Systematic Review (LSR)?
Living Systematic Reviews (LSRs) are comprehensive literature reviews that are continually updated, incorporating relevant new evidence as it becomes available when published in databases and clinical trial registries, which is used to conduct meta-analyses for various safety, immunogenicity and efficacy endpoints.
A robust methodological framework, including PRISMA guidelines for reporting, ensures high-quality evidence synthesis. Including a diverse range of populations, such as children, pregnant persons, and adults, allows for a comprehensive evaluation of vaccine safety and efficacy among key at-risk groups.
🌐 Interactive Insights
The LRS findings are publicly accessible online – Explore the latest results and updates at safeinpregnancy.org.
The LSR team has developed a dashboard with a description of the methods and key outputs, as well as a web-based tool featuring *automated* meta-analyses and proportion analyses to evaluate the safety, immunogenicity and efficacy/effectiveness of specific vaccines or platforms on selected populations.
📜 Protocols and Transparency
Our two CHIKV protocols (pregnant individuals and infants, children, adolescents) were registered on PROSPERO on March 4, 2024.
📅 Updates and Milestones
Results and updates, including the meta-analysis function, have been available online since October 1, 2024.
Primary evidence on safety, effectiveness, and immunogenicity of identified CHKV vaccines is updated every two weeks.
The CHKV vaccine development pipeline is updated every 6 months.
🌍 The CHKV LSR is a collaboration between:
- the Special Populations work group team of Safety Platform for Emergency vACcines (SPEAC)
- Instituto de Efectividad Clínica y Sanitaria (IECS) in Buenos Aires, Argentina
- Tulane University, in New Orleans, USA.
